Effect of Cocoa Pod Husk Proanthocyanidins Extract on Cyclooxigenase-2 (COX-2) Expression in Gingival Crevicular Fluid of Periodontitis Rats

Inflammation of periodontal tissue due to Porphyromonas gingivalis which invades the gingival activity virulence factors. This causes host immune system changes and increases COX-2 production in so resulting excessive destruction. The aim this study was analyze potency proanthocyanidins extract cacao pod husk inhibit expression rat sulcus fluid. 3 groups study, namely negative control, positive treatment. In all groups, on 0 day, fluid taken, then rats were induced by once every days for 2 weeks; control group a placebo gel applied treatment day 7, 14, 28 serial crevicular collection carried out 28. observed using ELISA method. statistical test used Anova. There significant difference expressions (p <0.05). decrease given 10% extract. Bioactive compounds cocoa potential reduce periodontitis rats. Article Details